Synthesis and anticancer activity of some pyrido[2,3-]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors.

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ID: 61344
2019
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Abstract
Due to emergence of resistance to available anticancer agents, there is a need to search for new cytotoxic agents. Pyrido[2,3-]pyrimidines (-) and their tricyclic derivatives () were prepared and screened for their cytotoxicity against breast MCF-7, prostate PC-3 and lung A-549 cancer cell lines as well as normal fibroblasts WI-38. The most active compounds were and compared with doxorubicin. Moreover, compounds and induced apoptosis in PC-3 and MCF-7, respectively via activation of CASP3 (in PC-3 only), Bax, p53 and down regulation of Bcl2 in addition to CDK4/6 inhibition. Pyrido[2,3-]pyrimidine represents an important core for discovery of new potent cytotoxic agents acting on the cell cycle via apoptosis induction through either intrinsic or extrinsic pathways.
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abbas2019synthesisfuture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Abbas, Safinaz E-S;George, Riham F;Samir, Eman M;Aref, Mostafa Ma;Abdel-Aziz, Hatem A;
Journal Future medicinal chemistry
Year 2019
DOI
10.4155/fmc-2019-0050
URL
Keywords
anticancer apoptosis cell cycle cdk pyrido[2,3-d]pyrimidine

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