Facile synthesis of multi-walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin.

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ID: 61339
2019
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Abstract
The motive of work was to develop a multi-walled carbon nanoplatform through facile method for transportation of potential anticancer drug doxorubicin (DOX). Folic acid (FA)-ethylene diamine (EDA) anchored and acid functionalised MWCNTs were covalently grafted with DOX via π-π stacking interaction. The resultant composite was corroborated by H NMR, FTIR, XRD, EDX, SEM, and DSC study. The drug entrapment efficiency of FA-conjugated MWCNT was found high and stability study revealed its suitability in biological system. FA-EDA-MWCNTs-DOX conjugate demonstrated a significant anticancer activity on human breast cancer MCF-7 cells. MTT study revealed the lesser cytotoxicity of folate-conjugated MWCNTs. The obtained results demonstrated the targeting specificity of FA-conjugate via overexpressed folate receptor deemed greater scientific value to overcome multidrug protection during cancer therapy. The proposed strategy is a gentle contribution towards development of biocompatible targeted drug delivery and offers potential to address the current challenges in cancer therapy.
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uttekar2019facileiet Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Uttekar, Pravin S;Lakade, Sameer H;Beldar, Vijay K;Harde, Minal T;
Journal iet nanobiotechnology
Year 2019
DOI
10.1049/iet-nbt.2018.5421
URL
Keywords
multidrug resistance tumor bivalent p-gp securinine virosecurinine

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