Inverse-micelle synthesis of doxorubicin-loaded alginate/chitosan nanoparticles and assessment of breast cancer cytotoxicity.

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ID: 61331
2019
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Abstract
Naturally-derived polysaccharides, such as alginate and chitosan, can be assembled to form nanocarriers for the delivery of therapeutic agents. Here we exploit the electrostatic complexation of alginate/chitosan in a water-in-oil (w/o) emulsion process to produce doxorubicin (DOX)-loaded nanoparticles (~80 nm) with exceptional spherical morphology and uniformity. This robust synthetic route utilizes an aqueous phase dispersed in a cyclohexane/dodecylamine organic phase and is capable of encapsulating DOX in the nanoparticle solution. The uptake and efficacy of this novel formulation was evaluated in a murine breast cancer cell line, 4T1, with comparable 72 h IC values of the nanoparticle solution (0.15 μg/mL) and free DOX (0.13 μg/mL). Overall, the favorable performance, physiochemical properties, and their facile production support these nanocarriers as promising platform for the delivery of aqueous soluble drugs.
Reference Key
rosch2019inversemicellecolloid Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rosch, Justin G;Winter, Hayden;DuRoss, Allison N;Sahay, Gaurav;Sun, Conroy;
Journal colloid and interface science communications
Year 2019
DOI
10.1016/j.colcom.2018.12.002
URL
Keywords
Breast cancer chitosan alginate doxorubicin cell viability

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