YKL-40, SAA1, CRP and PCT are promising biomarkers for intracranial severity assessment of traumatic brain injury: Relationship with Glasgow Coma Scale and CT volumetry.

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ID: 60795
2019
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Abstract
The volume and location of intracranial hematomas are well-known prognostic factors for traumatic brain injury (TBI). The aim of this study was to determine the relationship of serum biomarkers S100β, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), total tau (T-tau), phosphorylated neurofilament heavy chain (pNF-H), serum amyloid A 1 (SAA 1), C-reactive protein (CRP), procalcitonin (PCT), and chitinase-3-like protein 1 (YKL-40) with TBI severity and the amount and location of hemorrhagic traumatic lesions.A prospective observational cohort of 115 patients with Glasgow Coma Scale (GCS) 3-15 was evaluated. Intracranial lesion volume was measured from the semiautomatic segmentation of hematoma on CT using Analyze software. The establishment of possible biomarker cut-off points for intracranial lesion detection was estimated using Youden's Index (J) obtained from the area under the receiver operating characteristic curve (AUROC).SAA 1, YKL-40, PCT and S100β showed the most robust association with level of consciousness, both with total GCS and motor score. Biomarkers significantly correlated with volumetric measurements of subdural (SDH), subarachnoid (tSAH), intraparenchymal (ICH), intraventricular (IVH) and total amount of bleeding. The type of intracranial hemorrhage was associated with various release patterns of neurobiochemical markers.YKL-40, SAA 1, CRP and PCT combined with S100β were the most promising biomarkers to determine the presence, location and extent of traumatic intracranial lesions. Combination of biomarkers further increased the discriminatory capacity for the detection of intracranial bleeding.
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carabias2019ykl40world Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Carabias, Cristina Sánchez;Gomez, Pedro A;Panero, Irene;Eiriz, Carla;Castaño-León, Ana María;Egea, Javier;Lagares, Alfonso;, ;Paredes, Igor;Fernández Alén, Jose Antonio;Moreno-Gómez, Luis Miguel;García-Pérez, Daniel;Chico-Fernández, Mario;Barea-Mendoza, Jesús;
Journal world neurosurgery
Year 2019
DOI
S1878-8750(19)32587-2
URL
Keywords
Traumatic brain injury biomarkers intracranial hemorrhage ct volumetry glasgow coma scale

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