Development of a chemical fingerprint as a tool to distinguish closely related Tinospora species and quantitation of marker compounds.

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ID: 60752
2019
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Abstract
Tinospora species are morphologically similar. Several cases of human toxicity have been reported in association with T. crispa. A chemical fingerprint was developed to differentiate T. crispa from its closely related species and to quantitate its major furanoditerpenes namely as borapetosides B, C and F. The rapid, sensitive and repeatable method was established using ultra-high performance liquid chromatography coupled with photodiode array and single quadrupole electrospray mass spectrometry detectors using a flavonoid, two alkaloids, an amide and six diterpenoids. Qualitative and quantitative determination was performed by UHPLC-UV and confirmed by MS. The intra-day RSD for replicates was between 0.9 and 6.8% and inter-day RSD was between 1.2 and 9.1%. Recovery was 97-103 %. The method is useful to achieve decisiveness in not only identifying but also differentiating T. crispa from T. sinensis and other closely related Tinospora species. Seventeen Tinospora plant samples and seventeen dietary supplements claiming T. crispa, T. sinensis and T. cordifolia were analyzed. The newly developed and validated method successfully resulted in the conclusive identification of two dietary supplements to be mislabeled.
Reference Key
parveen2019developmentjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Parveen, Abidah;Wang, Yan-Hong;Fantoukh, Omer;Alhusban, Manal;Raman, Vijayasankar;Ali, Zulfiqar;Khan, Ikhlas A;
Journal Journal of pharmaceutical and biomedical analysis
Year 2019
DOI
S0731-7085(19)31237-3
URL
Keywords
dietary supplements borapetoside c magnoflorine t. crispa t. sinensis tinosineside a

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