Targeted brain delivery nanoparticles for malignant gliomas.

Clicks: 371
ID: 60737
2017
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Ranked #8 of 23 articles by views in nanomedicine (london, england)

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Abstract
Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB. Here, we present a comprehensive overview of the available therapeutic strategies developed against malignant gliomas based on 'actively targeted' NPs, the challenges of crossing the BBB and blood-brain tumor barrier as well as its mechanisms and a critical assessment of clinical studies that have used targeted NPs for the treatment of malignant gliomas. Finally, we discuss the potential of actively targeted NP-based strategies in clinical settings, its possible side effects and future directions for therapeutic applications. First draft submitted: 4 October 2016; Accepted for publication: 14 October 2016; Published online: 23 November 2016.
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pinto2017targetednanomedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pinto, Mauricio P;Arce, Maximiliano;Yameen, Basit;Vilos, Cristian;
Journal nanomedicine (london, england)
Year 2017
DOI
DOI not found
URL URL not found
Keywords
drug delivery nanomedicine gliomas blood–brain barrier blood–brain tumor barrier malignant gliomas targeted nanoparticles

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