Enhancing Luminol Electrochemiluminescence by Combined Use of Cobalt-Based Metal Organic Frameworks and Silver Nanoparticles and Its Application in Ultrasensitive Detection of Cardiac Troponin I.

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ID: 60692
2019
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Abstract
Electrochemiluminescence (ECL) has emerged as one of the most important methods for in vitro diagnosis and detection, but it is still limited in sensitivity for ultrasensitive biodetections. Fast and ultrasensitive detection of biomolecules is critical, especially for the clinical detection of cardiac troponin I (cTnI) for cardiac infarction diagnosis. In this study, an effective tactic was developed to enhance ECL efficiency of the luminol system, by combined use of Co-based metal organic frameworks (MOF), zeolitic imidazolate frameworks (ZIF-67), and luminol-capped Ag nanoparticles (luminol-AgNPs). The integration leads to a pronounced ∼115-fold enhancement in luminol ECL. On the basis of this fascinating sensing platform, a robust label-free ECL immunosensor was constructed for ultrasensitive detection of cTnI, the main marker of myocardial infarction, with good stability and a detection limit as low as 0.58 fg mL (S/N = 3).
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wang2019enhancinganalytical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Shanshan;Zhao, Yangyang;Wang, Minmin;Li, Haijuan;Saqib, Muhammad;Ge, Chunhua;Zhang, Xiangdong;Jin, Yongdong;
Journal Analytical chemistry
Year 2019
DOI
10.1021/acs.analchem.8b05443
URL
Keywords
Silver nanoparticles glutamic acid milk lysozyme localized surface plasmon resonance

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