Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances.

Clicks: 398
ID: 60369
2019
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Abstract
In recent decades a worldwide increase has been reported in the consumption of unhealthy high calorie diets associated with marked changes in meal nutrient composition, such as a higher intake of refined carbohydrates, which leads to the speculatation that changes in food habits have contributed to the current epidemic of obesity and type 2 diabetes. Among these refined carbohydrates, fructose has been deeply investigated and murine models of high fructose diet have emerged as useful tools to study dietary-induced insulin resistance, impaired glucose tolerance, dyslipidemia and alterations in glucose metabolism. Since oxidative stress has been demonstrated to play a key pathogenic role in the alterations described above, several lines of research have focused on the possible preventive effects of antioxidant/redox state regulation therapy, among which alpha-lipoic acid has been extensively investigated. The following references discussed support the fact that co-administration of alpha-lipoic acid normalized the changes generated by fructose rich diets, thereby making this compound a good therapeutic tool, also administered as a food supplement, to prevent endocrine-metabolic disturbances triggered by high fructose associated with obesity and type 2 diabetes at an early stage of development (prediabetes).
Reference Key
castro2019alphalipoicfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Castro, María Cecilia;Villagarcía, Hernán Gonzalo;Massa, María Laura;Francini, Flavio;
Journal Food & function
Year 2019
DOI
10.1039/c8fo01856a
URL
Keywords
prevalence diet complications incidence carbohydrates glycaemic index bad carbs glycaemic load good carbs ype 2 diabetes

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