TOR Signaling in Development, Metabolism, and Aging.

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2019
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Abstract
The arget f apamycin (TOR or mTOR) is a serine/threonine kinase that regulates growth, development, and behaviors by modulating protein synthesis, autophagy, and multiple other cellular processes in response to changes in nutrients and other cues. Over recent years, TOR has been studied intensively in mammalian cell culture and genetic systems because of its importance in growth, metabolism, cancer, and aging. Through its advantages for unbiased, and high-throughput, genetic and studies, has made major contributions to our understanding of TOR biology. Genetic analyses in the worm have revealed unexpected aspects of TOR functions and regulation, and have the potential to further expand our understanding of how growth and metabolic regulation influence development. In the aging field, has played a leading role in revealing the promise of TOR inhibition as a strategy for extending life span, and identifying mechanisms that function upstream and downstream of TOR to influence aging. Here, we review the state of the TOR field in , and focus on what we have learned about its functions in development, metabolism, and aging. We discuss knowledge gaps, including the potential pitfalls in translating findings back and forth across organisms, but also describe how TOR is important for biology, and how work has developed paradigms of great importance for the broader TOR field.
Reference Key
blackwell2019torgenetics Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Blackwell, T Keith;Sewell, Aileen K;Wu, Ziyun;Han, Min;
Journal Genetics
Year 2019
DOI
10.1534/genetics.119.302504
URL
Keywords
aging metabolism raptor caenorhabditis elegans development daf-15 nprl-2 nprl-3 nprl2 nprl3 raga-1 rsks-1 raga ragc rheb rheb-1 rictor s6 kinase tor torc1 torc2 wormbook growth regulation nutrient signaling sphingolipid

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