A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning.

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ID: 59574
2017
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Abstract
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.
Reference Key
wang2017aelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Qixuan;Oh, Ji Won;Lee, Hye-Lim;Dhar, Anukriti;Peng, Tao;Ramos, Raul;Guerrero-Juarez, Christian Fernando;Wang, Xiaojie;Zhao, Ran;Cao, Xiaoling;Le, Jonathan;Fuentes, Melisa A;Jocoy, Shelby C;Rossi, Antoni R;Vu, Brian;Pham, Kim;Wang, Xiaoyang;Mali, Nanda Maya;Park, Jung Min;Choi, June-Hyug;Lee, Hyunsu;Legrand, Julien M D;Kandyba, Eve;Kim, Jung Chul;Kim, Moonkyu;Foley, John;Yu, Zhengquan;Kobielak, Krzysztof;Andersen, Bogi;Khosrotehrani, Kiarash;Nie, Qing;Plikus, Maksim V;
Journal eLife
Year 2017
DOI
10.7554/eLife.22772
URL
Keywords
skin systems biology stem cells developmental biology mouse hair follicle computational biology pattern formation

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