Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine.

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ID: 59349
2019
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Abstract
Hapten contact hypersensitivity (CHS) elicits a well-documented inflammation response that can be used to illustrate training of immune cells through hapten-specific CHS memory. The education of hapten-specific memory T cells has been well-established, recent research in mice has expanded the "adaptive" characteristic of a memory response from solely a function of the adaptive immune system, to innate cells as well. To test whether similar responses are seen in a non-rodent model, we used hapten-specific CHS to measure the ear inflammation response of outbred pigs to dinitrofluorobenzene (DNFB), oxazolone (OXA), or vehicle controls. We adapted mouse innate memory literature protocols to the domestic pig model. Animals were challenged up to 32 days post initial sensitization exposure to the hapten, and specific ear swelling responses to this challenge were significant for 7, 21, and 32 days post-sensitization. We established hapten-specific CHS memory exists in a non-rodent model. We also developed a successful protocol for demonstrating these CHS responses in a porcine system.
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putz2019successfulplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Putz, E J;Putz, A M;Boettcher, A;Charley, S;Sauer, M;Palmer, M;Phillips, R;Hostetter, J;Loving, C L;Cunnick, J E;Tuggle, C K;
Journal PloS one
Year 2019
DOI
10.1371/journal.pone.0223483
URL
Keywords
Epidemiology environment ulcerative colitis inflammatory bowel disease crohn's disease

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