Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity

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2012
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Abstract
Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemiological and in vitro studies. Environmental air pollutants are a heterogeneous mixture of particles suspended into a liquid and gaseous phase which trigger the disruption of redox homeostasis—known under the term of cellular oxidative stress—in relation with the establishment of inflammation and cell death via necrosis, apoptosis, or autophagy. Activation or repression of the apoptotic process as an adaptative response to xenobiotics might lead to either acute or chronic toxicity. The purpose of this paper is to highlight the central role of oxidative stress induced by air pollutants and to focus on the subsequent cellular impacts ranging from cytoprotection to cytotoxicity by decreasing or stimulating apoptosis, respectively.
Reference Key
andreau2012healthbiochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andreau, Karine;Leroux, Melanie;Bouharrour, Aida;
Journal biochemistry research international
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/493894
Keywords
Organic Chemistry Medicine (General) Science gynecology and obstetrics education (general) biochemistry reproduction

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