Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2.

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ID: 59225
2019
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Abstract
The obligate intracellular bacterium Chlamydia trachomatis proliferates in the membranous compartment inclusion formed in host cells. The host ceramide transport protein CERT delivers ceramide from the endoplasmic reticulum to the Golgi complex for the synthesis of sphingomyelin (SM). C. trachomatis has been suggested to employ CERT to produce SM in the inclusion by host SM synthases (SMSs). Here, we found that C. trachomatis proliferates and produces infective progeny even in SMS1 and SMS2 double knockout HeLa cells, but not in the SMS1/SMS2/CERT triple knockout cells. Interestingly, infected cells convert ceramide to SM without host SMSs. These results suggest that C. trachomatis-infected cells can convert ceramide to SM without host SMSs after CERT-mediated transfer of ceramide to the inclusions.
Reference Key
tachida2019chlamydiafebs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tachida, Yuriko;Kumagai, Keigo;Sakai, Shota;Ando, Shuji;Yamaji, Toshiyuki;Hanada, Kentaro;
Journal FEBS Letters
Year 2019
DOI
10.1002/1873-3468.13632
URL
Keywords
inclusion sphingomyelin ceramide chlamydia trachomatis cert hela cells sgms1 sgms2

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