Texture Analysis of T1-weighted Contrast Enhanced Magnetic Resonance Imaging Potentially Predicts the Outcomes of the Patients with non-WNT/non-SHH Medulloblastoma.

To investigate whether tumor texture features derived from preoperative T1-weighted magnetic resonance imaging (MRI) are associated with overall survival (OS) of non-WNT/non-SHH medulloblastoma patients.We retrospectively reviewed 38 patients with non-WNT/non-SHH (encompassing group 3 and group 4) medulloblastoma treated surgery in our institution from 2013 to 2016. All patients were followed up for at least two years or until death. Primary tumor traditional parameters were evaluated, and texture features were extracted from preoperative T1-weighted MRI, including four features from the histogram matrix and six texture from Gray-level co-occurrence matrix (GLCM). Texture features were dichotomized into two subgroups based on their optimal cutoff values obtained from receiver operating characteristics curve analysis. Two-year overall survival (OS) was compared between the dichotomized subgroups using the Kaplan-Meier analysis and the log-rank test. Multivariate Cox regression analysis was performed to determine independent prognostic factors.The therapy regime was the only basic characteristic significantly related to 2-year OS (P=0.015). Two features of the GLCM were shown to be significantly associated with 24-month OS. Multivariate Cox regression analysis revealed that GLCM-Homogeneity (adjusted hazard ratio [HR], 0.145; P = 0.013) was an independent prognostic predictor for patients.Texture analysis on T1-weighted contrast-enhanced MRI potentially serves as prognostic predictor survival for patients with non-WNT/non-SHH medulloblastoma.