Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A.
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ID: 58292
2018
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Abstract
Two series of derivatives with 1,2,3-triazole as heterocyclic moiety of Jiyuan Oridonin A, a new ent-kaurene diterpenoid which was isolated from genus Isodon rubescens, were synthesized and biologically evaluated. All the derivatives possessed good anti-proliferative activities. Among them, compound 8g was found to significantly induce cell apoptosis and cell cycle arrest in MGC-803 via a series of signals activated by the increased intracellular ROS levels.
| Reference Key |
ke2018designbioorganic
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|---|---|
| Authors | Ke, Yu;Wang, Wang;Zhao, Long-Fei;Liang, Jian-Jia;Liu, Ying;Zhang, Xiao;Feng, Kai;Liu, Hong-Min; |
| Journal | bioorganic & medicinal chemistry |
| Year | 2018 |
| DOI |
S0968-0896(17)31573-0
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