Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents.

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ID: 58288
2019
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Abstract
A series of novel 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives have been synthesized in good to excellent yields. Through the copper-catalyzed azide-alkyne cycloaddition via reaction of 7-(prop-2-ynyl)-7H-pyrrolo[2,3-d]pyrimidine and aryl, heteroaryl and alkyl azides in the presence of CuSO·5HO and sodium ascorbate. These compounds were evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain. Most of these pyrrolopyrimidine-triazole hybrids exhibited good anti tubercular activity. The antimycobacterial assay results showed that the minimum inhibitory concentration of compounds 4q and 4r were 0.78 µg/mL. The molecular docking results also had shown highest Moldock score for same compounds. These novel compounds exhibited good inhibition activities and further structure-activity studies of the derivatives had shown promising features to use in antitubercular therapy.
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shiva-raju2019synthesisbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shiva Raju, Kasa;AnkiReddy, Sandeep;Sabitha, Gowravaram;Siva Krishna, Vagolu;Sriram, Dharmarajan;Bharathi Reddy, Kunduru;Rao Sagurthi, Someswar;
Journal Bioorganic & medicinal chemistry letters
Year 2019
DOI
S0960-894X(18)30903-X
URL
Keywords
triazoles molecular docking Mycobacterium tuberculosis pyrrolopyrimidines sar studies

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