Antiviral activity of itraconazole against type I feline coronavirus infection.

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ID: 58006
2019
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Abstract
Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
Reference Key
takano2019antiviralveterinary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Takano, Tomomi;Akiyama, Misuzu;Doki, Tomoyoshi;Hohdatsu, Tsutomu;
Journal veterinary research
Year 2019
DOI
10.1186/s13567-019-0625-3
URL
Keywords
mucormycosis acute myeloid leukemia unrelated bone marrow transplantation

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