Histoplasmosis, heart failure, hemolysis and haemophagocytic lymphohistiocytosis.

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ID: 57975
2019
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Abstract
Histoplasmosis is an endemic mycosis with global distribution, primarily reported in immunocompromised individuals. A 29-year old immunocompetent male presented with fever, hepatosplenomegaly and pancytopenia. His peripheral blood showed features suggestive of intravascular hemolysis and echocardiography showed features suggestive of pulmonary arterial hypertension. Bone marrow showed yeast with morphology suggestive of . Further investigations revealed hyperferritinemia, hypofibrinogenemia and increased triglycerides. With a diagnosis of progressive disseminated histoplasmosis with secondary Haemophagocytic lymphohistiocytosis, he was successfully treated with amphotericin B followed by itraconazole. We report this case to highlight the atypical and rare manifestations of histoplasmosis.
Reference Key
gupta2019histoplasmosisthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gupta, Nitin;Vinod, Kutty Sharada;Mittal, Ankit;Kumar, Aswin Pius Ajay;Kumar, Arvind;Wig, Naveet;
Journal The Pan African medical journal
Year 2019
DOI
10.11604/pamj.2019.32.43.14954
URL
Keywords
pulmonary arterial hypertension immunocompetent pancytopenia

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