Synthesis and Antibacterial Evaluation of Mannich Bases Derived from 1,2,4-Triazole.

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ID: 57967
2019
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Abstract
The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class of compounds.
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paneth2019synthesischemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Paneth, Agata;Trotsko, Nazar;Popiołek, Łukasz;Grzegorczyk, Agnieszka;Krzanowski, Tomasz;Janowska, Sara;Malm, Anna;Wujec, Monika;
Journal Chemistry & biodiversity
Year 2019
DOI
10.1002/cbdv.201900377
URL
Keywords
1,2,4-triazole antibacterial activity mannich base biological activity

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