A New Class of β-Pyrrolidino-1,2,3-Triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies.

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ID: 57922
2019
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Abstract
New 1,4-disubstituted β-pyrrolidino-1,2,3-triazoles were synthesized using a reusable copper-iodide-doped neutral alumina catalyst. Synthesis of diversely substituted triazoles and recyclability of CuI catalyst explains the broad scope of this protocol. The synthesized compounds were screened for their antimicrobial and anticancer properties. Most of the compounds showed significant antimicrobial activities against all the tested microorganisms compared to standard drugs. Furthermore, compounds , , , , , and showed moderate to potent activities against A549 and HepG-2 cells. In addition, compounds and displayed potential cytotoxicity activity against A549 cells with IC values of 72 ± 3.21 and 58 ± 2.31 µM, respectively. The molecular docking study revealed that some of the synthesized compounds exhibited comparable binding as co-crystalized ligands with the DNA topoisomerase IV and anaplastic lymphoma kinase receptors.
Reference Key
easwaramoorthi2019amolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Easwaramoorthi, Kaliyappan;Rajendran, Jeya A;Rao, Kella Chennakesava;Balachandran, Chandrasekar;Arun, Yuvaraj;Mahalingam, Sakkarapalayam M;Arumugam, Natarajan;Almansour, Abdulrahman I;Kumar, Raju Suresh;Al-Thamili, Dhaifallah M;Aoki, Shin;
Journal molecules
Year 2019
DOI
E3501
URL
https://www.mdpi.com/1420-3049/24/19/3501
Keywords
Antimicrobial activity anticancer activity docking studies β-adrenoceptors β–pyrrolidino-1,2,3-triazole polystyrene fluorescent sensor metal ions 1,8-naphthalimide photo-induced electron transfer

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