A New Class of β-Pyrrolidino-1,2,3-Triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies.
Clicks: 256
ID: 57922
2019
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Steady Performance
80.5
/100
234 views
187 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
New 1,4-disubstituted β-pyrrolidino-1,2,3-triazoles were synthesized using a reusable copper-iodide-doped neutral alumina catalyst. Synthesis of diversely substituted triazoles and recyclability of CuI catalyst explains the broad scope of this protocol. The synthesized compounds were screened for their antimicrobial and anticancer properties. Most of the compounds showed significant antimicrobial activities against all the tested microorganisms compared to standard drugs. Furthermore, compounds , , , , , and showed moderate to potent activities against A549 and HepG-2 cells. In addition, compounds and displayed potential cytotoxicity activity against A549 cells with IC values of 72 ± 3.21 and 58 ± 2.31 µM, respectively. The molecular docking study revealed that some of the synthesized compounds exhibited comparable binding as co-crystalized ligands with the DNA topoisomerase IV and anaplastic lymphoma kinase receptors.
| Reference Key |
easwaramoorthi2019amolecules
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Easwaramoorthi, Kaliyappan;Rajendran, Jeya A;Rao, Kella Chennakesava;Balachandran, Chandrasekar;Arun, Yuvaraj;Mahalingam, Sakkarapalayam M;Arumugam, Natarajan;Almansour, Abdulrahman I;Kumar, Raju Suresh;Al-Thamili, Dhaifallah M;Aoki, Shin; |
| Journal | molecules |
| Year | 2019 |
| DOI |
E3501
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.