Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation.

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2014
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Abstract
A one-pot protocol for the synthesis of N-aryl 1,2,3-triazoles from arenes by an iridium-catalyzed CH borylation/copper catalyzed azidation/click sequence is described. 1 mol % of Cu(OTf)2 was found to efficiently catalyze both the azidation and the click reaction. The applicability of this method is demonstrated by the late-stage chemoselective installation of 1,2,3-triazole moiety into unactivated molecules of pharmaceutical importance.
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srinivasan2014regioselectivechemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Srinivasan, Rajavel;Coyne, Anthony G;Abell, Chris;
Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Year 2014
DOI
10.1002/chem.201403021
URL
Keywords
Click chemistry synthetic methods ch borylation azidation

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