Thromboprophylaxis and Incidence of Venous Thromboembolism in Patients With Hemophilia A or B Who Underwent High-Risk Orthopedic Surgeries.

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ID: 57643
2016
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Ranked #1 of 4 articles by views in clinical and applied thrombosis/hemostasis : official journal of the international academy of clinical and applied thrombosis/hemostasis

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Abstract
Total hip replacement (THR) and total knee arthroplasty (TKA) carry a high risk of postoperative venous thromboembolism (VTE); therefore, anticoagulation prophylaxis is recommended in these patients. Unfortunately, there are no guidelines about VTE prophylaxis in patients with hemophilia who underwent these high-risk surgeries. To determine whether these patients have high risk of VTE, we conducted a retrospective study on patients with hemophilia who underwent elective THR/TKA at our institute from 2004 to 2012. Postoperatively, we collected information on duration and method of factor VIII/IX infusion, VTE-prophylaxis, and complications. There were 23 patients with hemophilia, 18 (78%) with hemophilia A and 5 (22%) with hemophilia B, who underwent high-risk surgeries (39% THR and 61% TKA). The VTE prophylaxis included sequential compression device, 12 (52%), and prophylactic enoxaparin, 1 (4%). Ten (43%) patients did not receive VTE prophylaxis. At 1-year follow-up, we did not find any evidence of clinical VTE in our patients. Better risk stratification is needed to identify patients who would benefit from pharmacological prophylaxis.
Reference Key
raza2016thromboprophylaxisclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Raza, Shahzad;Kale, Gautam;Kim, Daniel;Akbar, Syed A;Holm, Lisa;Naidzionak, Ulad;Hossain, Akm M;Dong, Xiang;Doll, Donald C;Freter, Carl E;Hopkins, Tamara;
Journal clinical and applied thrombosis/hemostasis : official journal of the international academy of clinical and applied thrombosis/hemostasis
Year 2016
DOI
10.1177/1076029614543139
URL
Keywords
orthopedics venous thromboembolism orthopedic surgery knee hemophilia hemophilia b hip arthroplasty replacement hemophilia a

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