Upstream sequence of the parahydroxyphenyl-pyruvate dioxygenase (melA) coding region leading to enhanced expression in Shewanella colwelliana.

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ID: 57036
1996
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Abstract
Hyperexpression of the enzyme, parahydroxyphenylpyruvate dioxygenase (pHPPH; melA), in the tyrosine degradative pathway yields excess homogentisic acid which oxidatively polymerizes to pyomelanin. Depression of melA in Shewanella colwelliana strain D was found to result from a single base pair transition upstream of the promoter. This was the sole lesion detected in pHPPH hyperexpressing strains. It is suggested that a T to C transition alters the mRNA structure, exposing the ribosome binding site, thereby enhancing translational efficiency.
Reference Key
eylem1996upstreammicrobios Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eylem, C L;Quintero, E J;Weiner, R M;
Journal microbios
Year 1996
DOI
DOI not found
URL URL not found
Keywords
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