Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.

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ID: 56909
2019
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Abstract
The cinnamamide (cinnamic acid amide and cinnamide) is a privileged scaffold present widely in a number of natural products. The scaffold acts as a useful template for designing and arriving at newly drug-like molecules with potential pharmacological activity. An attempt has been made to review the extensive occurrence of cinnamamide scaffold in many lead compounds reported for treating various diseases, their binding interactions with the therapeutic targets as well as mechanism of action and their structure-activity relationships. The discoveries of cinnamamide systems and some examples of unusual cinnamamides having an aromatic, aliphatic, and heterocyclic or other rings condensed to the basic cinnamamide structure also have been extensively covered in this review.
Reference Key
gaikwad2019cinnamamideeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gaikwad, Nikhil;Nanduri, Srinivas;Madhavi, Y V;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)30685-3
URL
Keywords
antiviral anticonvulsant anti-cancer antitubercular anti-inflammatory activity antidepressant anti-fungal activity anti-trypanosomal activity antimalarial activity cinnamamide tyrosinase inhibitor

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