Nanodiscs for Structural Biology in a Membranous Environment.

Clicks: 439
ID: 56292
2019
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Abstract
The structures of many membrane proteins have been analyzed in detergent micelles. However, the environment of detergent micelles differs somewhat from that of the lipid bilayer, where membrane proteins exhibit physiological functions. Therefore, a more membrane-like environment has been awaited for structural analysis of membrane proteins. Nanodiscs are "hockey-puck"-shaped lipid bilayer particles that distribute in a monodispersed manner in aqueous solution. We review how nanodiscs or protein-reconstituted nanodiscs are prepared and how they are utilized to analyze protein structure, dynamics, and interactions with lipid molecules using solution NMR and cryo-electron microscopy.
Reference Key
yokogawa2019nanodiscschemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yokogawa, Mariko;Fukuda, Masahiro;Osawa, Masanori;
Journal Chemical & pharmaceutical bulletin
Year 2019
DOI
10.1248/cpb.c18-00941
URL
Keywords
solution nmr structural analysis functional analysis cryo-electron microscopy membrane protein nanodisc

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