Kalman-like Self-Tuned Sensitivity in Biophysical Sensing.

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ID: 55961
2019
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Abstract
Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we argue that living cells can navigate these conflicting demands by dynamically tuning their environmental sensitivity. We analyze the circadian clock in Synechococcus elongatus, showing that clock-metabolism coupling can detect mismatch between clock predictions and the day-night light cycle, temporarily raise the clock's sensitivity to light changes, and thus re-entraining faster. We find analogous behavior in recent experiments on switching between slow and fast osmotic-stress-response pathways in yeast. In both cases, cells can raise their sensitivity to new external information in epochs of frequent challenging stress, much like a Kalman filter with adaptive gain in signal processing. Our work suggests a new class of experiments that probe the history dependence of environmental sensitivity in biophysical sensing mechanisms.
Reference Key
husain2019kalmanlikecell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Husain, Kabir;Pittayakanchit, Weerapat;Pattanayak, Gopal;Rust, Michael J;Murugan, Arvind;
Journal cell systems
Year 2019
DOI
S2405-4712(19)30306-0
URL
Keywords
cyanobacteria yeast circadian clock entrainment gain adaptation gain-bandwidth osmotic shock recursive bayesian estimation speed-accuracy

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