Differential protein expression in seminal plasma from fertile and infertile males

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ID: 55706
2014
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Abstract
Aim: The aim of this study was to analyze human seminal plasma proteins in association with male fertility status using the proteomic mass spectrometry technology Surface-Enhanced Laser Desorption Ionization Time-of-Flight (SELDI-TOF-MS). Materials and Methods: Semen analysis was performed using conventional methods. Protein profiles of the seminal plasma were obtained by SELDI-TOF mass spectrometry over a strong anion exchanger, ProteinChip® Q10 array. Results and Conclusion: We found statistically significant differences in motility and sperm count between fertile and infertile men. In addition, we observed ten seminal proteins that are significantly up-regulated in the infertile group. In conclusion, comparison of seminal plasma proteome in fertile and infertile men provides new aspects in the physiology of male fertility and might help in identifying novel markers of male infertility.
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j2014differentialjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J, Angela P Cadavid;Alvarez, Angela;Markert, Udo R;Maya, Walter Cardona;
Journal Journal of human reproductive sciences
Year 2014
DOI
DOI not found
URL
http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=3;spage=206;epage=211;aulast=Cadavid
Keywords
Medicine (General) Medicine Engineering (General). Civil engineering (General) Technology general works gynecology and obstetrics diseases of the genitourinary system. urology

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