Chronic mucocutaneous candidiasis: a look at genetic understanding

داء المبيضات المخاطي الجلدي المزمن: نظرة على الفهم الوراثي

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ID: 55701
2018
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Abstract
Chronic mucocutaneous candidiasis is an infectious phenotype characterized by recurrent or persistent infections in the skin, nails and mucous membranes produced by Candida sp. This is secondary to any alteration in the antifungal immunity, in which not only the production of IL-17, but any defect in the differentiation of the T lymphocytes towards their TH17 profile, play a fundamental role and will unchain a susceptibility to this infection; that depending on the genetic etiology, can be a syndromic manifestation with other associated infectious and endocrinological clinical characteristics. Here, we review in a practical, clear and concise manner, the genetic defects so far found to be involved in the appearance of chronic mucocutaneous candidiasis.
يُعد داء المبيضات المخاطي الجلدي المزمن نمطاً ظاهرياً عدوائياً يتسم بإصابات متكررة أو مستمرة في الجلد والأظافر والأغشية المخاطية تُحدثها فطور المبيّضة (*Candida sp.*). ويحدث ذلك نتيجة لأي اعتلال في المناعة المضادة للفطريات، حيث يؤدي إنتاج الإنترلوكين-17 (IL-17)، فضلاً عن أي خلل في تمايز الخلايا اللمفاوية التائية نحو مسارها TH17، دوراً جوهرياً يُفضي إلى زيادة القابلية للإصابة بهذه العدوى؛ والتي قد تمثل، اعتماداً على المسببات الوراثية، تظاهراً متلازمياً مصحوباً بخصائص سريرية إنتانية وغدية صماء أخرى مرافقة. ونستعرض هنا، بأسلوب عملي وواضح وموجز، الاعتلالات الجينية التي ثبت حتى الآن ضلوعها في نشوء داء المبيضات المخاطي الجلدي المزمن.
Reference Key
mara2018chroniciatreia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors María, Maya Rico, Ana;Nora, Cardona Castro,;
Journal iatreia
Year 2018
DOI
DOI not found
URL
http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/331161/20791227
Keywords
Medicine (General) Medicine Engineering (General). Civil engineering (General) Technology gynecology and obstetrics diseases of the genitourinary system. urology

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