Differential protein expression in seminal plasma from fertile and infertile males.

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ID: 55691
2014
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Abstract
The aim of this study was to analyze human seminal plasma proteins in association with male fertility status using the proteomic mass spectrometry technology Surface-Enhanced Laser Desorption Ionization Time-of-Flight (SELDI-TOF-MS).Semen analysis was performed using conventional methods. Protein profiles of the seminal plasma were obtained by SELDI-TOF mass spectrometry over a strong anion exchanger, ProteinChip(®) Q10 array.We found statistically significant differences in motility and sperm count between fertile and infertile men. In addition, we observed ten seminal proteins that are significantly up-regulated in the infertile group. In conclusion, comparison of seminal plasma proteome in fertile and infertile men provides new aspects in the physiology of male fertility and might help in identifying novel markers of male infertility.
Reference Key
cadavid-j2014differentialjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cadavid J, Angela P;Alvarez, Angela;Markert, Udo R;Cardona Maya, Walter;
Journal Journal of human reproductive sciences
Year 2014
DOI
10.4103/0974-1208.142485
URL
Keywords
Proteomics fertility seminal plasma surface-enhanced laser desorption ionization time-of-flight

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