Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

Clicks: 415
ID: 55601
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #2 of 6 articles by views in immunity

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells, we traced the developmental stages of monocytes differentiating into Kupffer cells and mapped the cellular interactions imprinting the Kupffer cell identity. Kupffer cell loss induced tumor necrosis factor (TNF)- and interleukin-1 (IL-1) receptor-dependent activation of stellate cells and endothelial cells, resulting in the transient production of chemokines and adhesion molecules orchestrating monocyte engraftment. Engrafted circulating monocytes transmigrated into the perisinusoidal space and acquired the liver-associated transcription factors inhibitor of DNA 3 (ID3) and liver X receptor-α (LXR-α). Coordinated interactions with hepatocytes induced ID3 expression, whereas endothelial cells and stellate cells induced LXR-α via a synergistic NOTCH-BMP pathway. This study shows that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Reference Key
bonnardel2019stellateimmunity Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bonnardel, Johnny;T'Jonck, Wouter;Gaublomme, Djoere;Browaeys, Robin;Scott, Charlotte L;Martens, Liesbet;Vanneste, Bavo;De Prijck, Sofie;Nedospasov, Sergei A;Kremer, Anna;Van Hamme, Evelien;Borghgraef, Peter;Toussaint, Wendy;De Bleser, Pieter;Mannaerts, Inge;Beschin, Alain;van Grunsven, Leo A;Lambrecht, Bart N;Taghon, Tom;Lippens, Saskia;Elewaut, Dirk;Saeys, Yvan;Guilliams, Martin;
Journal immunity
Year 2019
DOI
S1074-7613(19)30368-1
URL
Keywords
macrophage liver endothelial cell niche monocyte bmp9 id3 kupffer cell lxra notch nr1h3 fibroblast stellate cell

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.