Authentication analysis of MT-4 cells distributed by the NIH AIDS Reagent Program.
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2019
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Abstract
The MT-4 human T-cell line expresses HTLV-1 Tax and is permissive for replication of an HIV-1 gp41 mutant lacking the cytoplasmic tail. MT-4 cells (lot 150048), distributed by the NIH AIDS Reagent Program (NIH-ARP), were found to be Tax-deficient and unable to host replication of the gp41-truncated HIV-1 mutant. These findings, together with short tandem repeat (STR) profiling, established that lot 150048 are not MT-4 cells.
| Reference Key |
fernandez2019authenticationjournal
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| Authors | Fernandez, Melissa V;Delviks-Frankenberry, Krista A;Scheiblin, David A;Happel, Christine;Pathak, Vinay K;Freed, Eric O; |
| Journal | Journal of Virology |
| Year | 2019 |
| DOI |
JVI.01390-19
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