A New Red-NIR Fluorescent Probe for Time-Resolved Alka-line Phosphatase Detection with the Assistance of a Photo-Responsive Nanocontainer.

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ID: 55444
2019
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Abstract
The monitoring of alkaline phosphatase (ALP) activity in different tissues is significant for disease diagnosis and therapy. However, the time-resolved in vivo sensing of ALP activity remained unresolved. Herein, a novel red-near infrared fluores-cent ALP probe (Cl2-BDCM-ALP) based on dichloro substituted dicyanomethylene-4H-chromene derivative was designed and synthesized with high fluorescence efficiency and stability under biological pH range. By using Cl2-BDCM-ALP, ALP activity under acidic microenvironment such as tumor site can be sensitively imaged, which cannot be achieved by some previously reported ALP probes. By further loading the Cl2-BDCM-ALP into a near-infrared (NIR) light-responsive nanocon-tainner, time-resolved long-term imaging of ALP activity was facilely achieved with noninvasive NIR light remote control. Time-resolved variation of ALP activity of the drug induced acute liver injury mice was successfully monitored in vivo for the first time. This strategy holds great promise in the in situ ALP detection under broad pH range with temporal resolution.
Reference Key
jie2019aanalytical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jie, Xu;Wu, Mei;Yang, Haimei;Wei, Weili;
Journal Analytical chemistry
Year 2019
DOI
10.1021/acs.analchem.9b03497
URL
Keywords
fast measurement scheme fiber interferometer optical fiber sensor

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