Circuits for social learning: A unified model and application to Autism Spectrum Disorder.

Clicks: 325
ID: 55160
2019
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Abstract
Early life social experiences shape neural pathways in infants to develop lifelong social skills. This review presents the first unified circuit-based model of social learning that can be applied to early life social development, drawing together unique human developmental milestones, sensitive learning periods, and behavioral and neural scaffolds. Circuit domains for social learning are identified governing Activation, Integration, Discrimination, Response and Reward (AIDRR) to sculpt and drive human social learning. This unified model can be used to identify social delays earlier in development. We propose social impairments observed in Autism Spectrum Disorder are underpinned by early mistimed sensitive periods in brain development and alterations in amygdala development to disrupt the AIDRR circuits. This model directs how interventions can target neural circuits for social development and be applied early in life. To illustrate, the oxytocin intervention is explored in context of the AIDRR circuits. This model shifts the focus from applying possibly-related broad treatments, to specifying and targeting the relevant circuits, at the right time of development, to optimize social learning.
Reference Key
demayo2019circuitsneuroscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors DeMayo, Marilena M;Young, Larry J;Hickie, Ian B;Song, Yun Ju C;Guastella, Adam J;
Journal neuroscience and biobehavioral reviews
Year 2019
DOI
S0149-7634(19)30388-4
URL
Keywords
neurodevelopment biomarkers infant oxytocin amygdala parent-child interaction social development social cognition bonding research domain objective criteria social skills training

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