Pulmonary Embolism and Severe Asthma: Case Report and Literature Review.

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ID: 55159
2019
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Abstract
Pulmonary embolism is a life-threatening disease. Its development is generally thought to be due to causes collectively known as the Virchow's triad. Chronic inflammations are associated with the activation of coagulation and increased risks of venous thromboembolic events. Asthma is one of the chronic inflammatory diseases associated with procoagulants and antifibrinolytic activities in the airways. Coagulation is activated in patients with asthma with the following steps of pathophysiology: Increased tissue factor expression in various cell types, decreased activity of the anticoagulant protein C system and inhibition of fibrinolysis through over-production of plasminogen activator inhibitor type 1 (PAI-1). Asthma is therefore likely a risk factor for pulmonary embolism, especially in those patients with severe disease conditions together with frequent exacerbation. Here we present a case of severe asthma associated with coagulopathy and complicated by massive pulmonary embolism, presented with typical S1Q3T3 on electrocardiography (ECG) and massive thrombosis on computed tomography angiography, successfully treated with directed catheter thrombolytic therapy.
Reference Key
lee2019pulmonarymedicina Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lee, Po-Hsin;Fu, Pin-Kuei;
Journal Medicina (Kaunas, Lithuania)
Year 2019
DOI
E647
URL
Keywords
severe asthma coagulopathy massive pulmonary embolism plasminogen activator inhibitor type i (pai-1) tissue factor (tf) al–si–cu–mg alloys high strength and ductility insoluble phases soluble phases

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