Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies.

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ID: 54738
2019
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Ranked #122 of 292 articles by views in Proceedings of the National Academy of Sciences of the United States of America

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Abstract
We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum theory of tissue material properties in which the tissue is described as a 2-fluid system to account for its permeation by the interstitial fluid, and we include fluid pumping as well as active electric effects. Considering a spherical geometry and a polarized tissue, our work shows that fluid pumping and tissue flexoelectricity play a crucial role in lumen formation. We furthermore explore the large variety of long-time states that are accessible for the cell aggregate and its lumen. Our work reveals a role of the coupling of mechanical, electrical, and hydraulic phenomena in tissue lumen formation.
Reference Key
duclut2019fluidproceedings Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Duclut, Charlie;Sarkar, Niladri;Prost, Jacques;Jülicher, Frank;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2019
DOI
10.1073/pnas.1908481116
URL
Keywords
continuum theory of tissues lumen formation tissue biophysics tissue flexoelectricity tissue hydraulics

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