Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

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ID: 54682
2018
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Abstract
The inner ear is a fluid-filled closed-epithelial structure whose function requires maintenance of an internal hydrostatic pressure and fluid composition. The endolymphatic sac (ES) is a dead-end epithelial tube connected to the inner ear whose function is unclear. ES defects can cause distended ear tissue, a pathology often seen in hearing and balance disorders. Using live imaging of zebrafish larvae, we reveal that the ES undergoes cycles of slow pressure-driven inflation followed by rapid deflation. Absence of these cycles in mutants leads to distended ear tissue. Using serial-section electron microscopy and adaptive optics lattice light-sheet microscopy, we find a pressure relief valve in the ES comprised of partially separated apical junctions and dynamic overlapping basal lamellae that separate under pressure to release fluid. We propose that this lmx1-dependent pressure relief valve is required to maintain fluid homeostasis in the inner ear and other fluid-filled cavities.
Reference Key
swinburne2018lamellarelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Swinburne, Ian A;Mosaliganti, Kishore R;Upadhyayula, Srigokul;Liu, Tsung-Li;Hildebrand, David G C;Tsai, Tony Y-C;Chen, Anzhi;Al-Obeidi, Ebaa;Fass, Anna K;Malhotra, Samir;Engert, Florian;Lichtman, Jeff W;Kirchhausen, Tomas;Betzig, Eric;Megason, Sean G;
Journal eLife
Year 2018
DOI
10.7554/eLife.37131
URL
Keywords
cell biology stem cells developmental biology zebrafish pressure inner ear lamella timelapse valve

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