Therapeutic Efficacy of Orally Delivered Doxorubicin Nanoparticles in Rat Tongue Cancer Induced by 4-Nitroquinoline 1-Oxide

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2015
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Abstract
Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell carcinoma makes up about 94% of oral malignancies. The aim of the present study was to compare the efficacy of doxorubicin plus methotrexate - loaded nanoparticles on tongue squamous cell carcinoma induced by 4NQO and compare it with the commercial doxorubicin and methotrexate delivered orally on seventy SD male rats. Methods: 70 rats were divided into five groups. During the study, the animals were weighed by a digital scale once a week. Number of mortalities was recorded in the data collection forms. At the end of the treatment, biopsy samples were taken from rat tongues in order to evaluate the severity of dysplasia and the extent of cell proliferation. The results were analyzed using ANOVA, descriptive statistics and chi-square test. Results: No statistically significant difference was found in the mean weight of five groups (p>0.05). No significant relationship was found between groups and mortality rate (P = 0. 39). In addition, there was a significant relationship between groups and the degree of dysplasia (P <0.001). The statistical analysis showed a significant relationship between groups and the rate of cell proliferation (p <0.001). Conclusion: The results of the present study showed that the use of doxorubicin plus methotrexate - loaded nanoparticles orally had more therapeutic effects than commercial doxorubicin plus methotrexate.
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khiavi2015therapeuticadvanced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khiavi, Monir Moradzadeh;Rostami, Ahamd;Hamishekar, Hamed;Abassi, Mehran Mesgari;Aghbali, Amirala;Salehi, Roya;Abdollahi, Bita;Fotoohi, Soheila;Sina, Mahmud;
Journal advanced pharmaceutical bulletin
Year 2015
DOI
DOI not found
URL
http://journals.tbzmed.ac.ir/APB/Abstract/APB_1803_20140528194122
Keywords
chemistry Organic Chemistry Therapeutics. Pharmacology Biology (General) Medicine Materials of engineering and construction. Mechanics of materials Chemical technology Agriculture (General) toxicology. poisons agriculture

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