A Delicate Balance between Bacterial Iron and Reactive Oxygen Species Supports Optimal C. elegans Development.

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ID: 52841
2019
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Abstract
Iron is an essential micronutrient for all forms of life; low levels of iron cause human disease, while too much iron is toxic. Low iron levels induce reactive oxygen species (ROS) by disruption of the heme and iron-sulfur cluster-dependent electron transport chain (ETC). To identify bacterial metabolites that affect development, we screened the Keio Escherichia coli collection and uncovered 244 gene deletion mutants that slow Caenorhabditis elegans development. Several of these genes encode members of the ETC cytochrome bo oxidase complex, as well as iron importers. Surprisingly, either iron or anti-oxidant supplementation reversed the developmental delay. This suggests that low bacterial iron results in high bacterial ROS and vice versa, which causes oxidative stress in C. elegans that subsequently impairs mitochondrial function and delays development. Our data indicate that the bacterial diets of C. elegans provide precisely tailored amounts of iron to support proper development.
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zhang2019acell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Jingyan;Li, Xuhang;Olmedo, Maria;Holdorf, Amy D;Shang, Ye;Artal-Sanz, Marta;Yilmaz, L Safak;Walhout, Albertha J M;
Journal cell host & microbe
Year 2019
DOI
S1931-3128(19)30354-3
URL
Keywords
E. coli diet reactive oxygen species flux balance analysis metabolism iron c. elegans electron transport chain metabolic network modeling

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