Synthesis of Disulfide-Bridged N-Phenyl-N'-(Alkyl/Aryl/Heteroaryl)Urea Derivatives and Evaluation of Their Antimicrobial Activities.

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ID: 52814
2019
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Abstract
The recognition of new antimicrobial agents is extremely needed to overcome multidrug-resistant bacterial and tuberculosis infections. In the present study, eight novel substituted urea derivatives containing disulfide bond ( 10a-h ) were designed, synthesized and screened for their in vitro antimicrobial activities on standard strains of Gram-positive and Gram-negative bacteria as well as on Mycobacterium tuberculosis . According to the obtained results, antibacterial effects of the compounds were found to be considerably better than their antimycobacterial activities along with their weak cytotoxic effects. Molecular docking studies were performed to gain insights into the antibacterial activity mechanism of the synthesized compounds. The interactions and the orientation of compound 10a were found to be highly similar to the original ligand within the binding pocket E. faecalis β-ketoacyl acyl carrier protein synthase III (FabH). Finally, a theoretical study was established to predict the physicochemical properties of the compounds.
Reference Key
dogan2019synthesischemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Doğan, Şengül Dilem;Buran, Sümeyye;Gündüz, Miyase Gözde;Özkul, Ceren;Krishna, Vagolu Siva;Sriram, Dharmarajan;
Journal Chemistry & biodiversity
Year 2019
DOI
10.1002/cbdv.201900461
URL
Keywords
Urea antibacterial dimerization drug design, synthesis

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