Effects of degradation products of biomedical magnesium alloys on nitric oxide release from vascular endothelial cells.

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Abstract
Nitric oxide (NO) released by vascular endothelial cells (VECs), as a functional factor and signal pathway molecule, plays an important role in regulating vasodilation, inhibiting thrombosis, proliferation and inflammation. Therefore, numerous researches have reported the relationship between the NO level in VECs and the cardiovascular biomaterials' structure/functions. In recent years, biomedical magnesium (Mg) alloys have been widely studied and rapidly developed in the cardiovascular stent field for their biodegradable absorption property. However, influence of the Mg alloys' degradation products on VEC NO release is still unclear. In this work, Mg-Zn-Y-Nd, an Mg alloy widely applied on the biodegradable stent research, was investigated on the influence of the degradation time, the concentration and reaction time of degradation products on VEC NO release. The data showed that the degradation product concentration and the reaction time of degradation products had positive correlation with NO release, and the degradation time had negative correlation with NO release. All these influencing factors were controlled by the Mg alloy degradation behaviors. It was anticipated that it might make sense for the cardiovascular Mg alloy design aiming at VEC NO release and therapy.
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Authors Wang, Shuo;Zhu, Shi-Jie;Zhang, Xue-Qi;Li, Jing-An;Guan, Shao-Kang;
Journal Medical gas research
Year Year not found
DOI
10.4103/2045-9912.266991
URL
Keywords
anti-inflammation nitric oxide mg-zn-y-nd alloy anti-hyperplasia cardiovascular stent degradation products pro-endothelialization vascular endothelial cells

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