Phenanthroline- BuOK Promoted Intramolecular C-H Arylation of Indoles with ArI under Transition-Metal-Free Conditions.
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2018
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Abstract
The first example of phenanthroline- BuOK promoted intramolecular radical C-H arylation of N-(2-iodobenzyl)indoles without involvement of transition metals has been developed. A variety of substituted 6 H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient intramolecular cyclization using 1,10-phenanthroline in the presence of potassium tert-butoxide and chlorobenzene. This strategy provides a fast and versatile access to isoindolo[2,1- a]indole derivatives for the synthesis of pharmaceuticals and organic electroluminescent (EL) materials.
| Reference Key |
shan2018phenanthroline-
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| Authors | Shan, Xiang-Huan;Yang, Bo;Zheng, Hong-Xing;Qu, Jian-Ping;Kang, Yan-Biao; |
| Journal | Organic letters |
| Year | 2018 |
| DOI |
10.1021/acs.orglett.8b03449
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| URL | |
| Keywords | Keywords not found |
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