Current small animal models for LASV hearing loss.

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ID: 52172
2019
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Abstract
Lassa virus (LASV) is endemic in West Africa, causing an estimated 100000-300000 new infections and up to 5000-10000 deaths yearly. There are no vaccines and therapeutics are extremely limited. Typical case fatality rates are ∼1%, although a recent 2018 Nigerian outbreak featured an unprecedented 25.4% case fatality rate. Survivors of infection suffer a lifetime of sequelae with sudden onset sensorineural hearing loss (SNHL) being the most prevalent. The cause of this hearing loss remains unknown, and there is a critical need for further research on its mechanisms and potential therapeutics. The objective of this review is to outline the only currently available small animal model for LASV-induced hearing loss and to identify potential surrogate models.
Reference Key
sattler2019currentcurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sattler, Rachel A;Maruyama, Junki;Shehu, Nathan Y;Makishima, Tomoko;Paessler, Slobodan;
Journal current opinion in virology
Year 2019
DOI
S1879-6257(19)30068-9
URL
Keywords
hearing loss sudden sensorineural hearing loss tuning fork weber test

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