Current small animal models for LASV hearing loss.

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ID: 52172
2019
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Abstract
Lassa virus (LASV) is endemic in West Africa, causing an estimated 100000-300000 new infections and up to 5000-10000 deaths yearly. There are no vaccines and therapeutics are extremely limited. Typical case fatality rates are ∼1%, although a recent 2018 Nigerian outbreak featured an unprecedented 25.4% case fatality rate. Survivors of infection suffer a lifetime of sequelae with sudden onset sensorineural hearing loss (SNHL) being the most prevalent. The cause of this hearing loss remains unknown, and there is a critical need for further research on its mechanisms and potential therapeutics. The objective of this review is to outline the only currently available small animal model for LASV-induced hearing loss and to identify potential surrogate models.
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sattler2019currentcurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sattler, Rachel A;Maruyama, Junki;Shehu, Nathan Y;Makishima, Tomoko;Paessler, Slobodan;
Journal current opinion in virology
Year 2019
DOI
S1879-6257(19)30068-9
URL
Keywords
hearing loss sudden sensorineural hearing loss tuning fork weber test

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