CLINOPTILOLITE/PCL-PEG-PCL COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING APPLICATIONS.

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ID: 51725
2019
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Abstract
The aim of this study was to prepare and characterize highly porous clinoptilolite/poly(ε-caprolactone)-poly (ethylene glycol)-poly(ε-caprolactone) (CLN/PCEC) composite scaffolds. Scaffolds with different clinoptilolite contents (10% and 20%) were fabricated with reproducible solvent-free powder compression/particulate leaching technique. The scaffolds have interconnective porosity in the range of 55% to 76%. CLN-PCEC scaffolds showed negligible degradation within 8 weeks and displayed less swelling and higher bioactivity than PCEC scaffolds. Presence of clinoptilolite improved the mechanical properties. Highest compressive strength (5.6 MPa) and modulus (114.84 MPa) were reached with scaffold group containing 20% CLN. In vitro protein adsorption capacity of the scaffolds was also higher for CLN-PCEC scaffolds. These scaffolds had 0.95 mg protein/g scaffold adsorption capacity and also higher osteoinductivity in terms of enhanced ALP, OSP activities and intracellular calcium deposition. Stoichiometric apatite deposition (Ca/P=1.686) was observed during cellular proliferation analysis with human fetal osteoblasts cells. Thus, it can be suggested that CLN-PCEC composite scaffolds could be promising carriers for enhancement of bone regeneration in bone tissue engineering applications.
Reference Key
pazarceviren2019clinoptilolitepclpegpcljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pazarceviren, Ahmet Engin;Erdemli, Ozge;Keskin, Dilek;Tezcaner, Aysen;
Journal journal of tissue engineering and regenerative medicine
Year 2019
DOI
10.1002/term.2938
URL
Keywords
clinoptilolite bone tissue engineering pcl-peg-pcl particulate leaching powder compression solvent-free zeolite clinoptilolite pcl-peg-pcl bone union cortex development press-fit scaffold zeolite clinoptilolite pcl-peg-pcl bone union cortex development press-fit scaffold

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