Cytotoxic phenanthroline derivatives alter metallostasis and redox homeostasis in neuroblastoma cells.

Clicks: 570
ID: 517
2018
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #1 of 33 articles by views in oncotarget

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Copper homeostasis is generally investigated focusing on a single component of the metallostasis network. Here we address several of the factors controlling the metallostasis for neuroblastoma cells (SH-SY5Y) upon treatment with 2,9-dimethyl-1,10-phenanthroline-5,6-dione (phendione) and 2,9-dimethyl-1,10-phenanthroline (cuproindione). These compounds bind and transport copper inside cells, exert their cytotoxic activity through the induction of oxidative stress, causing apoptosis and alteration of the cellular redox and copper homeostasis network. The intracellular pathway ensured by copper transporters (Ctr1, ATP7A), chaperones (CCS, ATOX, COX 17, Sco1, Sco2), small molecules (GSH) and transcription factors (p53) is scrutinised.
Reference Key
naletova2018cytotoxic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Naletova, Irina;Satriano, Cristina;Curci, Alessandra;Margiotta, Nicola;Natile, Giovanni;Arena, Giuseppe;La Mendola, Diego;Nicoletti, Vincenzo Giuseppe;Rizzarelli, Enrico;
Journal oncotarget
Year 2018
DOI
10.18632/oncotarget.26346
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.