In silico determination of intracellular glycosylation and phosphorylation sites in human selectins: implications for biological function.

Clicks: 610
ID: 51438
2007
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Abstract
Post-translational modifications provide the proteins with the possibility to perform functions in addition to those determined by their primary sequence. However, analysis of multifunctional protein structures in the environment of cells and body fluids is made especially difficult by the presence of other interacting proteins. Bioinformatics tools are therefore helpful to predict protein multifunctionality through the identification of serine and threonine residues wherein the hydroxyl group is likely to become modified by phosphorylation or glycosylation. Moreover, serines and threonines where both modifications are likely to occur can also be predicted (YinYang sites), to suggest further functional versatility. Structural modifications of hydroxyl groups of P-, E-, and L-selectins have been predicted and possible functions resulting from such modifications are proposed. Functional changes of the three selectins are based on the assumption that transitory and reversible protein modifications by phosphate and O-GlcNAc cause specific conformational changes and generate binding sites for other proteins. The computer-assisted prediction of glycosylation and phosphorylation sites in selectins should be helpful to assess the contribution of dynamic protein modifications in selectin-mediated inflammatory responses and cell-cell adhesion processes that are difficult to determine experimentally.
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ahmad2007injournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ahmad, Ishtiaq;Hoessli, Daniel C;Gupta, Ramneek;Walker-Nasir, Evelyne;Rafik, Saleem M;Choudhary, M Iqbal;Shakoori, Abdul Rauf;, ;
Journal journal of cellular biochemistry
Year 2007
DOI
DOI not found
URL URL not found
Keywords
Cytotoxicity Proteomics systems biology metals risk assessment chemical mixtures chemical interactions dose response mixture toxicity

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