Clinically Relevant Post-Translational Modification Analyses-Maturing Workflows and Bioinformatics Tools.

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ID: 51424
2018
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Abstract
Post-translational modifications (PTMs) can occur soon after translation or at any stage in the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular localisation, activity, or the interactions proteins have with other proteins or biomolecular species. PTMs are crucial to our functional understanding of biology, and new quantitative mass spectrometry (MS) and bioinformatics workflows are maturing both in labelled multiplexed and label-free techniques, offering increasing coverage and new opportunities to study human health and disease. Techniques such as Data Independent Acquisition (DIA) are emerging as promising approaches due to their re-mining capability. Many bioinformatics tools have been developed to support the analysis of PTMs by mass spectrometry, from prediction and identifying PTM site assignment, open searches enabling better mining of unassigned mass spectra-many of which likely harbour PTMs-through to understanding PTM associations and interactions. The remaining challenge lies in extracting functional information from clinically relevant PTM studies. This review focuses on canvassing the options and progress of PTM analysis for large quantitative studies, from choosing the platform, through to data analysis, with an emphasis on clinically relevant samples such as plasma and other body fluids, and well-established tools and options for data interpretation.
Reference Key
pascovici2018clinicallyinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pascovici, Dana;Wu, Jemma X;McKay, Matthew J;Joseph, Chitra;Noor, Zainab;Kamath, Karthik;Wu, Yunqi;Ranganathan, Shoba;Gupta, Vivek;Mirzaei, Mehdi;
Journal International journal of molecular sciences
Year 2018
DOI
E16
URL
Keywords
quantitative proteomics ptm body fluids clinical samples post translational modification Magnetic resonance imaging multimodal imaging drug delivery systems photoluminescence theranostics magnetic targeting plga nanocapsules

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