(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities.

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ID: 51038
2019
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Abstract
Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of () flowers.The phytochemical and biological criteria of were in vitro investigated as well as in mouse xenograft model. extracts, specially CHCl and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CHCl extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, H-NMR and C-NMR. extracts, specially MeOH and CHCl extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively.Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of
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zahra2019molecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zahra, Maram Hussein;Salem, Tarek A R;El-Aarag, Bishoy;Yosri, Nermeen;El-Ghlban, Samah;Zaki, Kholoud;Marei, Amel H;Abd El-Wahed, Aida;Saeed, Aamer;Khatib, Alfi;AlAjmi, Mohamed F;Shathili, Abdulrahman M;Xiao, Jianbo;Khalifa, Shaden A M;El-Seedi, Hesham R;
Journal molecules
Year 2019
DOI
E2495
URL
Keywords
anti-oxidant anti-tumor 5,6-dehydrokawain alpinia zerumbet ehrlich ascites carcinoma

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