Nucleic Acid-Based Dual Cross-Linked Hydrogels for Tissue Repair via Directional Stem Cell Migration.

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ID: 50913
2019
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Abstract
tissue repair holds great potential as a cell-free regenerative strategy. A critical aspect of this approach is the selection of cell instructive materials that can efficiently regulate the defect microenvironment via the release of chemoattractant factors to mobilize and recruit endogenous stem cells toward the site of implantation. Here we report the design of a DNA-based hydrogel as a drug delivery platform for the sustained release of a promising chemoattractant, SDF-1α. The hydrogel is composed of chemically cross-linked DNA strands, which are bridged via silicate nanodisks (nSi). Silicate nanodisks electrostatically interact with the negatively charged DNA backbone resulting in the formation of a dual cross-linked nanocomposite hydrogel with a combination of chemical and physical cross-link points. The formulated nanocomposites display enhanced elasticity and mechanical toughness as compared to their nonsilicate containing counterparts. Moreover, the electrostatic interaction between nSi and SDF-1α leads to sustained release of the chemokine from the hydrogels. The bioactivity assays confirm the retention of chemotactic properties of the protein after its release. Overall, the dual cross-linked DNA-based hydrogel platform could be potentially used as a cell-instructive material for the recruitment of host stem cells to guide the process of tissue repair.
Reference Key
basu2019nucleicacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Basu, Sayantani;Alkiswani, Abdul-Rahman;Pacelli, Settimio;Paul, Arghya;
Journal ACS applied materials & interfaces
Year 2019
DOI
10.1021/acsami.9b10074
URL
Keywords
dna regenerative medicine sustained release dual-cross-linked nanosilicate stem cell recruitment

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