Partitioning the influence of ecology across scales on parasite evolution.
Tiklamalar: 302
ID: 50737
2019
Makale Kalitesi ve Performans Metrikleri
Genel Kalite
Improving Quality
0.0
/100
Etkilesim verilerini yapay zeka tabanli akademik kalite degerlendirmesiyle birlestirir
Okuyucu Etkilesimi
Steady Performance
79.1
/100
251 goruntulemeler
203 okuyucular
Trend
Yapay Zeka Kalite Degerlendirmesi
Analiz edilmedi
Ozet
Vector-borne parasites must succeed at three scales to persist: they must proliferate within a host, establish in vectors, and transmit back to hosts. Ecology outside the host undergoes dramatic seasonal and human-induced changes, but predicting parasite evolutionary responses requires integrating their success across scales. We develop a novel, data-driven model to titrate the evolutionary impact of ecology at multiple scales on human malaria parasites. We investigate how parasites invest in transmission versus proliferation, a life-history trait that influences disease severity and spread. We find that transmission investment controls the pattern of host infectiousness over the course of infection: a trade-off emerges between early and late infectiousness, and the optimal resolution of that trade-off depends on ecology outside the host. An expanding epidemic favors rapid proliferation, and can overwhelm the evolutionary influence of host recovery rates and mosquito population dynamics. If transmission investment and recovery rate are positively correlated, then ecology outside the host imposes potent selection for aggressive parasite proliferation at the expense of transmission. Any association between transmission investment and recovery represents a key unknown, one that is likely to influence whether the evolutionary consequences of interventions are beneficial or costly for human health.
| Referans Anahtari |
greischar2019partitioningevolution
Kullanarak makale yazarken otomatik alinti icin bu anahtari kullanin
SciMatic Makale Yoneticisi veya Tez Yoneticisi
|
|---|---|
| Yazarlar | Greischar, Megan A;Beck-Johnson, Lindsay M;Mideo, Nicole; |
| Dergi | evolution; international journal of organic evolution |
| Yil | 2019 |
| DOI |
10.1111/evo.13840
|
| URL | |
| Anahtar Kelimeler |
Atiflar
Atif bulunamadi. Atif eklemek icin yoneticiyle iletisime gecin: info@scimatic.org
Yorumlar
Henuz yorum yok. Bu makaleye ilk yorumu siz yapin.