Microwave-assisted synthesis of new pyrazole derivatives bearing 1,2,3-triazole scaffold as potential antimicrobial agents

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ID: 50541
2017
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Abstract
A new series of (E)-3-(3-(4-substituted phenyl)-1-phenyl-1H-pyrazol- 4-yl)-1-(2-hydroxy-4-((1-aryl-1H-1-2,3-triazol-4-yl)methoxy)phenyl)- prop-2-en-1-one derivatives was synthesized. The synthesis of the title compounds involved the 1,3-dipolar Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reaction of (E)-3-(3-(4-substituted phenyl)-1-phenyl-1H-pyrazol-4- -yl)-1-(2-hydroxy-4-(prop-2-yn-1-yloxy)phenyl)prop-2-en-1-ones with aromatic azides. The structures were confirmed by NMR, FT-IR, mass and elemental analysis. All the synthesized compounds (6a–j) were evaluated for their antimicrobial activity. Compounds 6a, 6d and 6e demonstrated promising inhibitory effects on both bacterial and fungal strains.
Reference Key
dongamanti2017microwaveassistedjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dongamanti, Ashok;Rangu, Kavitha;Srinivas, Gundu;Velagapuri, Hanumantha Rao;
Journal journal of the serbian chemical society
Year 2017
DOI
DOI not found
URL
http://www.doiserbia.nb.rs/img/doi/0352-5139/2017/0352-51391700016A.pdf
Keywords
chemistry Organic Chemistry Pharmacy and materia medica Biology (General) Science (General)

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